Cochrane Handbook for Systematic Reviews of Interventions

Author: Julian P. T. Higgins
Publisher: Wiley
ISBN: 9780470699515
Category : Medical
Languages : en
Pages : 672

Book Description
Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Asset Pricing

Author: John H. Cochrane
Publisher: Princeton University Press
ISBN: 1400829135
Category : Business & Economics
Languages : en
Pages : 552

Book Description
Winner of the prestigious Paul A. Samuelson Award for scholarly writing on lifelong financial security, John Cochrane's Asset Pricing now appears in a revised edition that unifies and brings the science of asset pricing up to date for advanced students and professionals. Cochrane traces the pricing of all assets back to a single idea—price equals expected discounted payoff—that captures the macro-economic risks underlying each security's value. By using a single, stochastic discount factor rather than a separate set of tricks for each asset class, Cochrane builds a unified account of modern asset pricing. He presents applications to stocks, bonds, and options. Each model—consumption based, CAPM, multifactor, term structure, and option pricing—is derived as a different specification of the discounted factor. The discount factor framework also leads to a state-space geometry for mean-variance frontiers and asset pricing models. It puts payoffs in different states of nature on the axes rather than mean and variance of return, leading to a new and conveniently linear geometrical representation of asset pricing ideas. Cochrane approaches empirical work with the Generalized Method of Moments, which studies sample average prices and discounted payoffs to determine whether price does equal expected discounted payoff. He translates between the discount factor, GMM, and state-space language and the beta, mean-variance, and regression language common in empirical work and earlier theory. The book also includes a review of recent empirical work on return predictability, value and other puzzles in the cross section, and equity premium puzzles and their resolution. Written to be a summary for academics and professionals as well as a textbook, this book condenses and advances recent scholarship in financial economics.

Cochrane the Dauntless

Author: David Cordingly
Publisher: A&C Black
ISBN: 1408822571
Category : Biography & Autobiography
Languages : en
Pages : 448

Book Description
Patrick O'Brian, C.S. Forester and Captain Marryat all based their literary heroes on Thomas Cochrane, but Cochrane's exploits were far more daring and exciting than those of his fictional counterparts. He was a man of action, whose bold and impulsive nature meant he was often his own worst enemy. Writing with gripping narrative skill and drawing on his own travels and original research, Cordingly tells the rip-roaring story of a flawed Romantic hero who helped define his age.

Biology of Plant Volatiles

Author: Eran Pichersky
Publisher: CRC Press
ISBN: 0429849257
Category : Nature
Languages : en
Pages : 398

Book Description
Plant volatiles—compounds emitted from plant organs to interact with the surrounding environment—play essential roles in attracting pollinators and defending against herbivores and pathogenes, plant-plant signaling, and abiotic stress responses. Biology of Plant Volatiles, with contributions from leading international groups of distinguished scientists in the field, explores the major aspects of plant scent biology. Responding to new developments in the detection of the complex compound structures of volatiles, this book details the composition and biosynthesis of plant volatiles and their mode of emission. It explains the function and significance of volatiles for plants as well as insects and microbes whose interactions with plants are affected by these compounds. The content also explores the biotechnological and commercial potential for the manipulation of plant volatiles. Features: Combines widely scattered literature in a single volume for the first time, covering all important aspects of plant volatiles, from their chemical structures to their biosynthesis to their roles in the interactions of plants with their biotic and abiotic environment Takes an interdisciplinary approach, providing multilevel analysis from chemistry and genes to enzymology, cell biology, organismal biology and ecology Includes up-to-date methodologies in plant scent biology research, from molecular biology and enzymology to functional genomics This book will be a touchstone for future research on the many applications of plant volatiles and is aimed at plant biologists, entomologists, evolutionary biologists and researchers in the horticulture and perfume industries.

The Cochrane Collaboration

Author: Alan Cassels
Publisher:
ISBN: 9781927755303
Category : Medical
Languages : en
Pages : 224

Book Description
"The Cochrane Collaboration... rivals the Human Genome Project in its potential implications for modern medicine." - C. David Naylor, "The Lancet" "How can we have a rational health service if we don't know which of the things being done in it are useful and which are useless or possibly even harmful?" - Archie Cochrane, in "Effectiveness and Efficiency," 1972 What's hocus-pocus and what really works? In the complex, ever-evolving realm of modern medicine, how can you even begin to understand what's hocus-pocus and what really works? Best-selling author and researcher Alan Cassels answers with a single word: "Cochrane." Though largely unknown to the public, the Cochrane Collaboration is made up of more than 30,000 medical researchers and consumer representatives from more than 100 countries - unbiased experts and investigators who parse the scienceof modern health care and delve deep into the evidence (or lack thereof) to determine what works and what doesn't. In this frank, factual and entertaining volume, Cassels draws from more than 160 interviews to shed light on this international cadre of medical truth-seekers whose rigorous work helps prevent medical misjudgement, reduce unnecessary suffering, preserve lives and circumvent the squandering of billions of dollars. ABOUT THE AUTHOR - ALAN CASSELS Alan Cassels is a University of Victoria health policy researcher and a trusted media commentator on medical policy issues. He is the co-author of the internationally bestselling book "Selling Sickness," and a frequent contributor to magazines, newspapers and radio programs."

The Fiscal Theory of the Price Level

Author: John H. Cochrane
Publisher: Princeton University Press
ISBN: 0691242240
Category : Business & Economics
Languages : en
Pages : 584

Book Description
"Inflation, in which all prices and wages in an economy rise, is mysterious. If a war breaks out in the Middle East, and the price of oil goes up, the mechanism is no great mystery-supply and demand often work pretty visibly. But if you ask the grocer why the price of bread is higher, he or she will blame the wholesaler, who will blame the baker, who will blame the wheat supplier, and so on. Perhaps the ultimate cause is a government printing more money, but there is really no way to know this for certain but to sit down in an office with statistics, armed with some decent economic theory. But current economic theory doesn't really explain why we haven't seen inflation for so long, and more and more economists think that current theory doesn't hold together, or provide much guidance for how central banks should behave if inflation does break out. Many also worry that central banks have much less power over the economy than they think they do, and much less understanding of the mechanism behind what power they do have. The Fiscal Theory of the Price Level is a comprehensive new approach to monetary policy. Economist John Cochrane argues that money has value because the government accepts it for tax payments. This insight, he argues, leads to a deep re-reading of monetary policy and institutions. Inflation comes when a government is unable to repay its debts, rather than from mismanagement of the split of debt between money and bonds. In the book, he will analyze institutional design, historical episodes, and compare fiscal theory to the Keynesian and new-Keynesian theory based on interest rate targets, and to monetarism. The book offers an overview and introduction to the range of contemporary monetary economics and history of thought as well as the fiscal theory"--

The Aesthetic Value of the World

Author: Tom Cochrane
Publisher: Oxford University Press
ISBN: 0192665073
Category : Philosophy
Languages : en
Pages : 238

Book Description
In The Aesthetic Value of the World, Tom Cochrane defends Aestheticism, the claim that everything is aesthetically valuable and that a life lived in pursuit of aesthetic value can be a particularly good one. Furthermore, in distilling aesthetic qualities, artists have a special role to play in teaching us to recognize values; a critical component of virtue. Cochrane grounds his account upon an analysis of aesthetic value as 'objectified final value', which is underwritten by an original psychological claim that all aesthetic values are distal versions of practical values. This is followed by systematic accounts of beauty, sublimity, comedy, drama, and tragedy, as well as appendix entries on the cute, the cool, the kitsch, the uncanny, the horrific, the erotic, and the furious.

When AIDS Began

Author: Michelle Cochrane
Publisher: Routledge
ISBN: 1135960836
Category : Medical
Languages : en
Pages : 346

Book Description
By examining the early outbreaks in San Francisco, Cochrane unfolds the "creation" of AIDS in one geographic location and then traces how and why major claims about the transmission of HIV were made, extrapolated and then disseminated to the rest of the world - all important factors in understanding this disease.

The Emotional Mind

Author: Tom Cochrane
Publisher: Cambridge University Press
ISBN: 110842967X
Category : Philosophy
Languages : en
Pages : 247

Book Description
This book develops an original control theory of the emotions and related affective states, providing new perspectives on how the mind works as a whole. Discussing pains and pleasures, moods and behaviours, and character and personality, the book will be important for readers interested in the philosophy and cognitive science of emotion.

Your Creative Mind

Author: Scott Cochrane
Publisher: Red Wheel/Weiser
ISBN: 1632659549
Category : Business & Economics
Languages : en
Pages : 211

Book Description
Too many companies limit their strategic thinking by focusing on what they already know how to do. Executives are expected to set concrete objectives and create detailed, step-by-step plans to reach them. This approach may satisfy short-term considerations like quarterly earnings reports, but it produces modest innovation and evolutionary development at best. As a result, the business can find itself in a performance plateau that it cannot seem to break out of.In Your Creative Mind, you will discover an entirely different approach to the creative process. You will learn:How to catapult your company out of a performance plateau and into dynamic growth, expansion, and market leadership.How to move beyond classic groupthink and unleash your true creative power.How to become a trend leader and paradigm shifter by harnessing the secrets of the power of creation.How to innovate your way into the most beneficial business relationships you can imagine.Using the practical techniques and steps described in Your Creative Mind will infuse your company with creative power and drive innovation. Break free of business as usual and create the dynamic growth you deserve!