Author: Jean-Philippe Chippaux Publisher: Krieger Publishing Company ISBN: 9781575242729 Category : Antivenins Languages : en Pages : 0
Book Description
Presenting a synthesis of the principal discoveries on venoms and envenomations, this text describes the paleontology and classification of snakes as well as the biochemistry and toxicology of venoms to explain the theoretical basis of the envenomation and its treatment.
Author: P. Gopalakrishnakone Publisher: Springer ISBN: 9789400764095 Category : Medical Languages : en Pages : 0
Book Description
In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.
Author: Mark O'Shea Publisher: Bloomsbury Academic ISBN: 9781843309727 Category : Poisonous snakes Languages : en Pages : 160
Book Description
All major and unusual venomous snakes, their range, habitats and venom, along with personal anecdotes (including snakebite stories) feature in this excellent book. Written by Mark O'Shea - one of the leading authorities on reptiles.
Author: C.-Y. Lee Publisher: Springer ISBN: 9783642669149 Category : Medical Languages : en Pages : 1132
Book Description
The past decade has been a period of explosion of knowledge on the chemistry and pharmacology of snake toxins. Thanks to the development of protein chemistry, nearly a hundred snake toxins have been purified and sequenced, representing one of the largest families of sequenced proteins. Moreover, the mode of action of these toxins has been largely elucidated by the concerted efforts of pharmacologists, electro physiologists, and biochemists. As a result of these studies, some of the snake toxins, e.g., a-bungarotoxin and cobra neurotoxins, have been extensively used as specific markers in the study of the acetylcholine receptors. Indeed, without the discovery of these snake toxins, our knowledge of the structure and function of nicotinic acetylcholine receptors would not have advanced so rapidly. The contribution of snake venom research to the biomedical sciences is not limited to the study of cholinergic receptors. Being one of the most concentrated enzyme sources in nature, snake venoms are also valuable tools in biochemical research. Venom phosphodiesterase, for example, has been widely used for structural studies of nucleic acids; proteinase, for the sequence studies of proteins and pep tides ; phospholipase A , for lipid research; and L-amino acid oxidase for identifying optical z isomers of amino acids. Furthermore, snake venoms have proven to be useful agents for clarifying some basic concepts on blood coagulation and some venom enzymes, e.g., thrombin-like enzymes and pro coagulants have been used as therapeutic agents.
Author: Stephen P. Mackessy Publisher: CRC Press ISBN: 0429623453 Category : Nature Languages : en Pages : 912
Book Description
A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.
Author: Jutta Schickore Publisher: University of Chicago Press ISBN: 022675989X Category : History Languages : en Pages : 323
Book Description
Scientists’ views on what makes an experiment successful have developed dramatically throughout history. Different criteria for proper experimentation were privileged at different times, entirely new criteria for securing experimental results emerged, and the meaning of commitment to experimentation altered. In About Method, Schickore captures this complex trajectory of change from 1660 to the twentieth century through the history of snake venom research. As experiments with poisonous snakes and venom were both challenging and controversial, the experimenters produced very detailed accounts of their investigations, which go back three hundred years—making venom research uniquely suited for such a long-term study. By analyzing key episodes in the transformation of venom research, Schickore is able to draw out the factors that have shaped methods discourse in science. About Method shows that methodological advancement throughout history has not been simply a steady progression toward better, more sophisticated and improved methodologies of experimentation. Rather, it was a progression in awareness of the obstacles and limitations that scientists face in developing strategies to probe the myriad unknown complexities of nature. The first long-term history of this development and of snake venom research, About Method offers a major contribution to integrated history and philosophy of science.
Author: Kurt F. Stocker Publisher: CRC Press ISBN: 9780849358463 Category : Medical Languages : en Pages : 284
Book Description
This fascinating book provides actual knowledge on evolution, anatomy habits, and classification of venomous snakes. It presents detailed, updated information on physicochemical, biochemical, and pharmacological characteristics of biomedically relevant snake venom proteins, their practical use and potential. This volume includes particular sections concerning neurotoxins and their application in neurophysiological and muscular research, snake venom proteins affecting the complement system, as well as the large field of snake venom components affecting the hemostatic and fibrinolytic system. Written in a comprehensive manner, this work communicates to the reader the importance of preventing the extinction of venomous snake species as the carriers of unique genetic information. This interesting book is a must for all who are involved with thrombosis, hemotology, toxinology, neurochemistry, as well as animal toxins within biological, medical or pharmaceutical education.
Author: Jean-Philippe Chippaux
Author: P. Gopalakrishnakone
Author: Jay Fox
Author: Mark O'Shea
Author: C.-Y. Lee
Author: Stephen P. Mackessy
Author: Jutta Schickore
Author: Kurt F. Stocker
Author: Scott Shupe
Author: Hideyo Noguchi