Targeted Learning

Author: Mark J. van der Laan
Publisher: Springer Science & Business Media
ISBN: 1441997822
Category : Mathematics
Languages : en
Pages : 628

Book Description
The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.

KS2 English

Author: Bonney Emma
Publisher:
ISBN: 9781782941316
Category : English language
Languages : en
Pages : 0

Book Description

Targeted

Author: Brittany Kaiser
Publisher: HarperCollins
ISBN: 0062965808
Category : Political Science
Languages : en
Pages : 435

Book Description
An “important and gripping” memoir by the woman who blew the whistle on Cambridge Analytica and the data industry’s unethical practices (The Washington Post). When Brittany Kaiser joined Cambridge Analytica—the UK-based political consulting firm funded by conservative billionaire and Donald Trump patron Robert Mercer—she was an idealistic young professional, a veteran of Barack Obama’s 2008 campaign with degrees in human rights law and international relations. Her goal was to utilize data for humanitarian purposes, most notably to prevent genocide and human rights abuses. But her experience inside Cambridge Analytica opened her eyes to the tremendous risks this unregulated industry poses to privacy and democracy. In this explosive memoir, she reveals the disturbing truth about the multi-billion-dollar data industry, revealing how companies are getting richer using our personal information and exposing how Cambridge Analytica exploited weaknesses in privacy laws to help elect Donald Trump in 2016. Targeted is Kaiser’s eyewitness chronicle of the dramatic and disturbing story of the rise and fall of Cambridge Analytica. She reveals how Facebook’s lax policies and lack of sufficient national laws allowed voters to be manipulated in both Britain and the US, where personal data was weaponized to spread fake news and racist messaging during the Brexit vote and the 2016 election. In the aftermath, as she became aware of the horrifying reality of what Cambridge Analytica had done, Kaiser made the difficult choice to expose the truth. Risking her career, relationships, and personal safety, she told authorities about the industry’s unethical practices, eventually testifying before Parliament about the company’s Brexit efforts and helping Special Counsel Robert Mueller’s investigation into Russian interference in the 2016 election, alongside at least ten other international investigations. Packed with never-before-publicly-told stories, Targeted goes inside the secretive meetings with Trump campaign personnel—and makes the case that legal oversight of the data industry is not only justifiable but essential to ensuring the long-term safety of our democracy. “Captivating and revelatory.” —Publishers Weekly (starred review) Includes photographs

A Beginner's Guide to Targeted Cancer Treatments

Author: Elaine Vickers
Publisher: John Wiley & Sons
ISBN: 1119126835
Category : Medical
Languages : en
Pages : 359

Book Description
Highly Commended in the category of Oncology at the British Medical Association Awards 2019 The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Targeted

Author: Stephen Hunter
Publisher: Simon and Schuster
ISBN: 1982169796
Category : Fiction
Languages : en
Pages : 384

Book Description
"After being accused of reckless endangerment and forced to answer to the U.S. Congress, master sniper Bob Lee Swagger must protect political hostages in a once-in-a-lifetime standoff"--

Targeted Cyber Attacks

Author: Aditya Sood
Publisher: Syngress
ISBN: 0128006196
Category : Computers
Languages : en
Pages : 159

Book Description
Cyber-crime increasingly impacts both the online and offline world, and targeted attacks play a significant role in disrupting services in both. Targeted attacks are those that are aimed at a particular individual, group, or type of site or service. Unlike worms and viruses that usually attack indiscriminately, targeted attacks involve intelligence-gathering and planning to a degree that drastically changes its profile. Individuals, corporations, and even governments are facing new threats from targeted attacks. Targeted Cyber Attacks examines real-world examples of directed attacks and provides insight into what techniques and resources are used to stage these attacks so that you can counter them more effectively. - A well-structured introduction into the world of targeted cyber-attacks - Includes analysis of real-world attacks - Written by cyber-security researchers and experts

Targeted Radionuclide Therapy

Author: Tod W. Speer
Publisher: Lippincott Williams & Wilkins
ISBN: 1451153260
Category : Medical
Languages : en
Pages : 564

Book Description
Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

The Brain-Targeted Teaching Model for 21st-Century Schools

Author: Mariale M. Hardiman
Publisher: Corwin Press
ISBN: 1412991986
Category : Education
Languages : en
Pages : 257

Book Description
Compatible with other professional development programs, this model shows how to apply relevant research from educational and cognitive neuroscience to classroom settings through a pedagogical framework. The model's six components are: 1) Establish the emotional connection to learning; 2) Develop the physical learning environment; 3) Design the learning experience; 4) Teach for the mastery of content, skills, and concepts; 5) Teach for the extension and application of knowledge; 6) Evaluate learning. --Book cover.

Targeted Killing in International Law

Author: Nils Melzer
Publisher: Oxford University Press on Demand
ISBN: 0199533164
Category : Law
Languages : en
Pages : 523

Book Description
This title examines the international lawfulness of state-sponsored targeted killings in military and police operations. Analysing recent state practice and jurisprudence, it establishes when targeted killing may be considered lawful, and what legal restraints are imposed on the practice in times of war and peace.

Targeted

Author: Kendra Elliot
Publisher: Montlake Romance
ISBN: 9781503935044
Category : Murder
Languages : en
Pages : 0

Book Description
On his quiet fishing trip, Detective Mason Callahan finds the body of his boss, Denny Schefte, near their remote Oregon cabin. The FBI assigns the case to Special Agent Ava McLane, Mason's fiancae, when they learn of the mask left at the scene. The FBI realizes that they are hunting a serial killer that targets police officers.