Life Out of Sequence

Author: Hallam Stevens
Publisher: University of Chicago Press
ISBN: 022608034X
Category : Science
Languages : en
Pages : 303

Book Description
Thirty years ago, the most likely place to find a biologist was standing at a laboratory bench, peering down a microscope, surrounded by flasks of chemicals and petri dishes full of bacteria. Today, you are just as likely to find him or her in a room that looks more like an office, poring over lines of code on computer screens. The use of computers in biology has radically transformed who biologists are, what they do, and how they understand life. In Life Out of Sequence, Hallam Stevens looks inside this new landscape of digital scientific work. Stevens chronicles the emergence of bioinformatics—the mode of working across and between biology, computing, mathematics, and statistics—from the 1960s to the present, seeking to understand how knowledge about life is made in and through virtual spaces. He shows how scientific data moves from living organisms into DNA sequencing machines, through software, and into databases, images, and scientific publications. What he reveals is a biology very different from the one of predigital days: a biology that includes not only biologists but also highly interdisciplinary teams of managers and workers; a biology that is more centered on DNA sequencing, but one that understands sequence in terms of dynamic cascades and highly interconnected networks. Life Out of Sequence thus offers the computational biology community welcome context for their own work while also giving the public a frontline perspective of what is going on in this rapidly changing field.

Life Out of Sequence

Author: Hallam Stevens
Publisher:
ISBN: 9781299850781
Category : Computers
Languages : en
Pages : 294

Book Description
Thirty years ago, the most likely place to find a biologist was standing at a laboratory bench, peering down a microscope, surrounded by flasks of chemicals and petri dishes full of bacteria. Today, you are just as likely to find him or her in a room that looks more like an office, poring over lines of code on computer screens. The use of computers in biology has radically transformed who biologists are, what they do, and how they understand life. In "Life Out of Sequence," Hallam Stevens looks inside this new landscape of digital scientific work. Stevens chronicles the emergence of bioinformatics the mode of working across and between biology, computing, mathematics, and statistics from the 1960s to the present, seeking to understand how knowledge about life is made in and through virtual spaces. He shows how scientific data moves from living organisms into DNA sequencing machines, through software, and into databases, images, and scientific publications. What he reveals is a biology very different from the one of predigital days: a biology that includes not only biologists but also highly interdisciplinary teams of managers and workers; a biology that is more centered on DNA sequencing, but one that understands sequence in terms of dynamic cascades and highly interconnected networks. "Life Out of Sequence" thus offers the computational biology community welcome context for their own work while also giving the public a frontline perspective of what is going on in this rapidly changing field. "

Biological Sequence Analysis

Author: Richard Durbin
Publisher: Cambridge University Press
ISBN: 113945739X
Category : Science
Languages : en
Pages : 372

Book Description
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Problems and Solutions in Biological Sequence Analysis

Author: Mark Borodovsky
Publisher: Cambridge University Press
ISBN: 1139458124
Category : Science
Languages : en
Pages : 15

Book Description
This book is the first of its kind to provide a large collection of bioinformatics problems with accompanying solutions. Notably, the problem set includes all of the problems offered in Biological Sequence Analysis, by Durbin et al. (Cambridge, 1998), widely adopted as a required text for bioinformatics courses at leading universities worldwide. Although many of the problems included in Biological Sequence Analysis as exercises for its readers have been repeatedly used for homework and tests, no detailed solutions for the problems were available. Bioinformatics instructors had therefore frequently expressed a need for fully worked solutions and a larger set of problems for use on courses. This book provides just that: following the same structure as Biological Sequence Analysis and significantly extending the set of workable problems, it will facilitate a better understanding of the contents of the chapters in BSA and will help its readers develop problem-solving skills that are vitally important for conducting successful research in the growing field of bioinformatics. All of the material has been class-tested by the authors at Georgia Tech, where the first ever MSc degree program in Bioinformatics was held.

Sequence

Author: Lori Andrews
Publisher: Macmillan
ISBN: 9780312942458
Category : Fiction
Languages : en
Pages : 340

Book Description
Geneticist Alexandra Blake uses her expertise to investigate a serial killer plaguing military bases across the country, but when an another murder hits close to home, Alex and her boyfriend, a Texas congressman, find their lives in danger.

Sequence Analysis in a Nutshell: A Guide to Tools

Author: Scott Markel
Publisher: "O'Reilly Media, Inc."
ISBN: 9780596004941
Category : Computers
Languages : en
Pages : 308

Book Description
This work pulls together all of the vital information about the most commonly used databases, analytical tools, and tables used in sequence analysis.

Advances in Sequence Analysis: Theory, Method, Applications

Author: Philippe Blanchard
Publisher: Springer
ISBN: 3319049690
Category : Social Science
Languages : en
Pages : 308

Book Description
This book gives a general view of sequence analysis, the statistical study of successions of states or events. It includes innovative contributions on life course studies, transitions into and out of employment, contemporaneous and historical careers, and political trajectories. The approach presented in this book is now central to the life-course perspective and the study of social processes more generally. This volume promotes the dialogue between approaches to sequence analysis that developed separately, within traditions contrasted in space and disciplines. It includes the latest developments in sequential concepts, coding, atypical datasets and time patterns, optimal matching and alternative algorithms, survey optimization, and visualization. Field studies include original sequential material related to parenting in 19th-century Belgium, higher education and work in Finland and Italy, family formation before and after German reunification, French Jews persecuted in occupied France, long-term trends in electoral participation, and regime democratization. Overall the book reassesses the classical uses of sequences and it promotes new ways of collecting, formatting, representing and processing them. The introduction provides basic sequential concepts and tools, as well as a history of the method. Chapters are presented in a way that is both accessible to the beginner and informative to the expert.

The Judge of Ages

Author: John C. Wright
Publisher: Macmillan
ISBN: 0765329298
Category : Fiction
Languages : en
Pages : 381

Book Description
The year is 10,515 AD. The Hyades Armada, traveling at near lightspeed, will reach Earth in just four centuries to assess humanity's value as slaves. For the last 8,000 years, two opposing factions have labored to meet the alien threat in very different ways. One of them is Ximen del Azarchel, immortal leader of the mutineers from the starship Hermetic and self-appointed Master of the World, who has allowed his followers to tamper continuously with the evolutionary destiny of Man, creating one bizarre race after another in an apparent search for a species the Hyades will find worthy of conquest. The other is Menelaus Montrose, the posthuman Judge of Ages, whose cryonic Tombs beneath the surface of Earth have preserved survivors from each epoch created by the Hermeticists. Montrose intends to thwart the alien invaders any way he can, and to remain alive long enough to be reunited with his bride Rania, who is on a seventy-millennia journey to confront the Hyades' masters, tens of thousands of light-years away. Now, with the countdown to the Hyades' arrival nearing its end, del Azarchel and Montrose square off for what is to be their final showdown for the fate of Earth, a battle of gunfire and cliometric calculus; powered armor and posthuman intelligence. Judge of Ages is the wildly inventive third volume in a series exploring future history and human evolution from John C. Wright.

DIY MFA

Author: Gabriela Pereira
Publisher: Penguin
ISBN: 1599639343
Category : Language Arts & Disciplines
Languages : en
Pages : 306

Book Description
Get the Knowledge Without the College! You are a writer. You dream of sharing your words with the world, and you're willing to put in the hard work to achieve success. You may have even considered earning your MFA, but for whatever reason--tuition costs, the time commitment, or other responsibilities--you've never been able to do it. Or maybe you've been looking for a self-guided approach so you don't have to go back to school. This book is for you. DIY MFA is the do-it-yourself alternative to a Master of Fine Arts in creative writing. By combining the three main components of a traditional MFA--writing, reading, and community--it teaches you how to craft compelling stories, engage your readers, and publish your work. Inside you'll learn how to: • Set customized goals for writing and learning. • Generate ideas on demand. • Outline your book from beginning to end. • Breathe life into your characters. • Master point of view, voice, dialogue, and more. • Read with a "writer's eye" to emulate the techniques of others. • Network like a pro, get the most out of writing workshops, and submit your work successfully. Writing belongs to everyone--not only those who earn a degree. With DIY MFA, you can take charge of your writing, produce high-quality work, get published, and build a writing career.

SINthetic

Author: J.T. Nicholas
Publisher: Rebel Base Books
ISBN: 1635730074
Category : Fiction
Languages : en
Pages : 177

Book Description
“Darkly engrossing, SINthetic shines a stark light on the age-old question, what does it mean to be human?” —Julie Kagawa, New York Times bestselling author The Artificial Evolution They look like us. Act like us. But they are not human. Created to perform the menial tasks real humans detest, Synths were designed with only a basic intelligence and minimal emotional response. It stands to reason that they have no rights. Like any technology, they are designed for human convenience. Disposable. In the city of New Lyons, Detective Jason Campbell is investigating a vicious crime: a female body found mutilated and left in the streets. Once the victim is identified as a Synth, the crime is designated no more than the destruction of property, and Campbell is pulled from the case. But when a mysterious stranger approaches Campbell and asks him to continue his investigation in secret, Campbell is dragged into a dark world of unimaginable corruption. One that leaves him questioning the true nature of humanity. And what he discovers is only the beginning . . .