Ras and Cancer in the 21st Century

Author: Linda VanAelst
Publisher: Perspectives Cshl
ISBN: 9781621822219
Category : Medical
Languages : en
Pages : 300

Book Description
Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids). The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.

Waking and the Reticular Activating System in Health and Disease

Author: Edgar Garcia-Rill
Publisher: Academic Press
ISBN: 0128016329
Category : Medical
Languages : en
Pages : 330

Book Description
Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders. First comprehensive overview on the RAS and its role in schizophrenia, major depression, autism, Parkinson’s, Alzheimer’s, and other neurologic and mental diseases Offers a new way of thinking about brain function and the role of the RAS in our waking lives Written by a leading translational neuroscience researcher with contributions by specialists in the field

The ras Superfamily of GTPases (1993)

Author: Juan Carlos Lacal
Publisher: CRC Press
ISBN: 1351356852
Category : Science
Languages : en
Pages : 548

Book Description
The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related GTPases. The book will benefit cell biologists, oncologists, neurobiologists, molecular biologists, and others interested in the topic.

The Protective Arm of the Renin Angiotensin System (RAS)

Author: Thomas Unger
Publisher: Academic Press
ISBN: 0128014857
Category : Medical
Languages : en
Pages : 312

Book Description
The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

Ras Superfamily Small G Proteins: Biology and Mechanisms 1

Author: Alfred Wittinghofer
Publisher: Springer
ISBN: 3709118069
Category : Science
Languages : en
Pages : 447

Book Description
This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.

Conquering RAS

Author: Asfar Azmi
Publisher: Academic Press
ISBN: 0128035412
Category : Medical
Languages : en
Pages : 296

Book Description
Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities Showcases recent advancements in RAS research under one comprehensive volume Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research

Breaking the HEC-RAS Code

Author: Christopher Goodell
Publisher: H2ls
ISBN: 9780990891802
Category : HEC-RAS (Computer program).
Languages : en
Pages : 264

Book Description
One of the most powerful, yet relatively unknown features available in HEC-RAS is the HECRASController. TheHECRASController API has a wealth of procedures which allow a programmer to manipulate HEC-RAS externally by setting input data, retrieving input or output data, and performing common functions such as opening and closing HEC-RAS, changing plans, running HEC-RAS, and plotting output. HECRASController applications are seemingly endless. Not only can the retrieval and post-processing of output be automated, but with the HECRASController, real-time modeling and probabilistic experiments like Monte Carlo are possible. If you have HEC-RAS on your computer, you already have the HECRASController! "Breaking the HEC-RAS Code" explains how the HECRASController works, provides example applications of the HECRASController, and catalogs the vast array of programming procedures (with explanations and examples on how to use them) embedded in the HECRASController. This is a "must-have" book for all HEC-RAS users. Professionals: Give yourself an edge for the next proposal and do something groundbreaking with HEC-RAS. Students: Make yourself marketable by adding the skills offered in this book.

Shringar - the Ras Raj

Author: Ved Bhatnagar
Publisher: Abhinav Publications
ISBN: 8170174252
Category : Art
Languages : en
Pages : 120

Book Description
The Shringar poetry is not simply a fresh school of poetry but is, in many respects, comparable to the great English romantic poetry excelling in the delineation of nature and flight of imagination. It is a unique effort of bringing under the umbrella of ras poetry, music, sculpture and painting, and a rare mix of scholarship and popular writing.

Your Brain at Work

Author: David Rock
Publisher: Harper Collins
ISBN: 0061943541
Category : Business & Economics
Languages : en
Pages : 310

Book Description
In Your Brain at Work, David Rock takes readers inside the heads—literally—of a modern two-career couple as they mentally process their workday to reveal how we can better organize, prioritize, remember, and process our daily lives. Rock, the author of Quiet Leadership and Personal Best, shows how it’s possible for this couple, and thus the reader, not only to survive in today’s overwhelming work environment but succeed in it—and still feel energized and accomplished at the end of the day.

The Last Skin

Author: Barbara Ras
Publisher: Penguin
ISBN: 1101222891
Category : Poetry
Languages : en
Pages : 80

Book Description
A third collection from a poet whose "beautiful sentences weave the miraculous and mundane into a single, luminous tapestry" (The Atlanta Journal-Constitution) Barbara has won acclaim for fluid and graceful poems that touch on the small occurrences and mysteries of daily life in the hopes of finding the secret meaning beneath them. Both intimate and wide ranging, her work is unafraid of big subjects and big feelings, and sometimes comedic. Her third collection, The Last Skin, extends and develops these qualities, offering landscapes and characters both domestic and exotic, in poignant personal lyrics of precise description that investigate beauty, grief, death, fragility, time, and loss. Here is a poet engaged with the spirit as well as the political, blending the give and take of the world into her own ecstatic rhythms.