Author: Ian LowePublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
The Half-Life of Facts
Author: Samuel ArbesmanPublisher: Penguin
ISBN: 159184651X
Category : Philosophy
Languages : en
Pages : 258
Book Description
New insights from the science of science Facts change all the time. Smoking has gone from doctor recommended to deadly. We used to think the Earth was the center of the universe and that the brontosaurus was a real dinosaur. In short, what we know about the world is constantly changing. Samuel Arbesman shows us how knowledge in most fields evolves systematically and predictably, and how this evolution unfolds in a fascinating way that can have a powerful impact on our lives. He takes us through a wide variety of fields, including those that change quickly, over the course of a few years, or over the span of centuries.
Principles and Practice of Clinical Trial Medicine
Author: Richard ChinPublisher: Elsevier
ISBN: 0080557937
Category : Medical
Languages : en
Pages : 560
Book Description
Clinical trials are an important part of medicine and healthcare today, deciding which treatments we use to treat patients. Anyone involved in healthcare today must know the basics of running and interpreting clinical trial data. Written in an easy-to-understand style by authors who have considerable expertise and experience in both academia and industry, Principles and Practice of Clinical Trial Medicine covers all of the basics of clinical trials, from legal and ethical issues to statistics, to patient recruitment and reporting results. - Jargon-free writing style enables those with less experience to run their own clinical trials and interpret data - Book contains an ideal mix of theory and practice so researchers will understand both the rationale and logistics to clinical trial medicine - Expert authorship whose experience includes running clinical trials in an academic as well as industry settings - Numerous illustrations reinforce and elucidate key concepts and add to the book's overall pedagogy
Caffeine for the Sustainment of Mental Task Performance
Author: Institute of MedicinePublisher: National Academies Press
ISBN: 0309082587
Category : Medical
Languages : en
Pages : 172
Book Description
This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.
The Great Mental Models, Volume 1
Author: Shane ParrishPublisher: Penguin
ISBN: 0593719972
Category : Business & Economics
Languages : en
Pages : 209
Book Description
Discover the essential thinking tools you’ve been missing with The Great Mental Models series by Shane Parrish, New York Times bestselling author and the mind behind the acclaimed Farnam Street blog and “The Knowledge Project” podcast. This first book in the series is your guide to learning the crucial thinking tools nobody ever taught you. Time and time again, great thinkers such as Charlie Munger and Warren Buffett have credited their success to mental models–representations of how something works that can scale onto other fields. Mastering a small number of mental models enables you to rapidly grasp new information, identify patterns others miss, and avoid the common mistakes that hold people back. The Great Mental Models: Volume 1, General Thinking Concepts shows you how making a few tiny changes in the way you think can deliver big results. Drawing on examples from history, business, art, and science, this book details nine of the most versatile, all-purpose mental models you can use right away to improve your decision making and productivity. This book will teach you how to: Avoid blind spots when looking at problems. Find non-obvious solutions. Anticipate and achieve desired outcomes. Play to your strengths, avoid your weaknesses, … and more. The Great Mental Models series demystifies once elusive concepts and illuminates rich knowledge that traditional education overlooks. This series is the most comprehensive and accessible guide on using mental models to better understand our world, solve problems, and gain an advantage.
Author: Aaron NovickAssessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis
Author: National Academies of Sciences, Engineering, and MedicinePublisher: National Academies Press
ISBN: 0309672104
Category : Medical
Languages : en
Pages : 427
Book Description
Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
Author: Joerg BluemelPublisher: Academic Press
ISBN: 012417146X
Category : Medical
Languages : en
Pages : 716
Book Description
The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
Molybdenum-99 for Medical Imaging
Author: National Academies of Sciences, Engineering, and MedicinePublisher: National Academies Press
ISBN: 0309445310
Category : Medical
Languages : en
Pages : 264
Book Description
The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world's supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa. Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.
The Half-Life
Author: Jon RaymondPublisher: Bloomsbury Publishing USA
ISBN: 159691887X
Category : Fiction
Languages : en
Pages : 370
Book Description
When Cookie Figowitz, the cook for a party of volatile fur trappers trekking through the Oregon Territory in the 1820s, joins up with the refugee Henry Brown, the two begin a wild ride that takes them from the virgin territory of the West all the way to China and back again. One hundred and sixty years later, Tina Plank, an unhappy teenager, meets Trixie, a girl with a troubled past, and the two become fast friends. But when two skeletons are accidentally unearthed from their common ground, the lives of Tina and Trixie, Cookie and Henry are brought together in unexpected and startling ways. Jonathan Raymond attended Swarthmore College. He was an editor at Plazm magazine and received his M.F.A. from New School University. He currently lives in Brooklyn, New York. "A marvelous novel...a mystery as rich as the history of the Oregon territory itself."-Vanity Fair "Raymond nimbly interweaves these parallel tales and manages to surprise...[a] subtle portrait of friendship and loss...[from] an astute, patient observer."-Entertainment Weekly "Raymond's debut novel teems with carefully researched period details, intrigue...yet it never feels overstuffed."-Washington Post "With The Half-Life, [Raymond] has come home prospecting for literary gold ...Oregon has given him something back."-San Francisco Chronicle "Quietly stunning...Raymond is a kind of stealth bomber of the epic."-Newsday "Terrific...The Half-Life gazes upon those fierce but ephemeral attachments that evade the history books. Multiple plots elegantly veer across the sprawling terrain."-Village Voice
