Melatonin, Neuroprotective Agents and Antidepressant Therapy

Author: Francisco López-Muñoz
Publisher: Springer
ISBN: 8132228030
Category : Medical
Languages : en
Pages : 917

Book Description
This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .

The Melatonin Miracle

Author: Walter Pierpaoli
Publisher: Simon and Schuster
ISBN: 0671534351
Category : Medical
Languages : en
Pages : 340

Book Description
In this book two of the world's leading medical researchers explains how melatonin works. It already prevents jet-lag and research suggests it controls the aging process, fights disease, boosts the immune system, lowers cholesterol & relieves stress.

Melatonin

Author: Russel J. Reiter
Publisher: Bantam
ISBN: 0553574841
Category : Health & Fitness
Languages : en
Pages : 417

Book Description
Would you believe that something could: Extend your youth by more than ten years? Boost your immune system in two weeks' time? Help prevent heart disease, Alzheimer's, Parkinson's, diabetes, and cataracts? Cut your recovery time from jet lag in half? Offer not just cancer prevention but a key to a cure? All in a widely available non-prescription capsule? It's true--and it's called melatonin. This remarkable book represents a major breakthrough in human health and life extension studies. It reveals cutting-edge research on melatonin--a natural hormone produced deep within the brain--that is revolutionizing our understanding of life. Melatonin helps determine how fast we age, how effectively we fight off disease and toxins, and how well we sleep. Melatonin is the most comprehensive, up-to-date, and authoritative book available about this amazing substance. Dr. Russel J. Reiter is one of the world's leading experts in the field. During more than thirty years of pioneering research, he has uncovered many of melatonin's unique properties-- including its role as the most powerful antioxidant in the body. In this book he reveals what he and other scientists around the world have only recently discovered about melatonin's remarkable potential to: Increase immune response dramatically Greatly improve existing treatments for cancer and AIDS Lower cholesterol and blood pressure Put you to sleep as effectively as a prescription drug--without side effects Improve mood and reduce symptoms of PMS Prevent the free radical damage that underlies aging Neutralize the dangerous side effects of mammograms, X-rays, and surgery In Melatonin, Reiter offers a complete, three-phase program to help you take advantage of this new information right now. First, he helps you pinpoint the habits, hidden environmental hazards, and common medications that may be diminishing your natural supply of melatonin. Next, he explains how you can naturally stimulate your production of this life-giving hormone. Finally, he provides a complete guide to melatonin supplements, including safe and effective doses, the best kind to buy, and when and how to take them. With all the suspense of a medical detective story, Melatonin reveals clue by tantalizing clue all of the amazing properties of this "hidden" wonder hormone, much the way they presented themselves to Dr. Reiter and his colleagues. The result is a book that only an insider could write--a book as exciting to read as it is vital to your health and the health of those you love.

Melatonin

Author: Venkatramanujan Srinivasan
Publisher: CRC Press
ISBN: 1482220091
Category : Medical
Languages : en
Pages : 576

Book Description
There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.

Melatonin for treatment of sleep disorders

Author:
Publisher:
ISBN:
Category : Melatonin
Languages : en
Pages :

Book Description

Melatonin in the Promotion of Health

Author: Ronald Ross Watson
Publisher: CRC Press
ISBN: 1439839808
Category : Medical
Languages : en
Pages : 572

Book Description
Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993, it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in variou

Melatonin

Author: Locke Hughes
Publisher: Ritual Wellness
ISBN: 9781454937661
Category : Melatonin
Languages : en
Pages : 0

Book Description
Melatonin takes a deep dive into the workings of this essential, all-natural hormone, which regulates sleep and the body's circadian rhythm. Learn about its effects on the body, how to harness its benefits, and how to take supplements safely. Twenty recipes for snacks and elixirs that encourage the melatonin production, along with an exploration of 30 calming bedtime routines, offer the guidance you'll need to catch some zzz's.

Melatonin and the Mammalian Pineal Gland

Author: Josephine Arendt
Publisher: Springer Science & Business Media
ISBN: 9780412536007
Category : Science
Languages : en
Pages : 364

Book Description
This volume provides the reader with an overview of an intriguing and interdisciplinary field of research. For the first time the mammalian pineal gland, its mode of action and its physiological effects are discussed in a comprehensive, single-authored work.

Tryptophan, Serotonin, and Melatonin

Author: Gerald Huether
Publisher: Springer Science & Business Media
ISBN: 1461547091
Category : Medical
Languages : en
Pages : 824

Book Description
This volume contains the proceedings of the Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY), held at the University of Hamburg, Germany, from October 10 to 14, 1998. At this meeting the recent developments in the field of tryptophan research were presented by leading researchers from all over the world in 81 oral and 48 poster contri butions. Research on tryptophan and its derivatives provides an inexhaustible subject. At the conference we tried to compose a multifacetted picture of the recent investiga tions through contributions from the major disciplines involved. Thus, we tried to strike a balance between basic research topics and clinical, nutritional or industrial applica tions. We offered workshops on tryptophan (in sleep and mood), melatonjn, IDO-acti vation and the eosinophilia-myalgia syndrome (EMS) as a platform for intensive discussion for the participants. In these proceedings many contributions are multidisciplinary and have practical or theoretical implications for different research fields. Hence, we have organized this volume in nine main chapters according to basic disciplines and subjects. We are aware that this classification is artificial, but we hope that it is the best compromise for contributors and readers.

The Pineal Gland and Cancer

Author: C. Bartsch
Publisher: Springer Science & Business Media
ISBN: 364259512X
Category : Medical
Languages : en
Pages : 979

Book Description
The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal - tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels. Yet unidentified low-molecular-weight pineal substances with tumor-inhibiting capacity, a possible involvement of melatonin in electromagnetic field effects on cancer, and the oncotherapeutic potential of melatonin are also addressed. The encouraging results should incite further research to elucidate the exact nature of the link between the pineal gland and cancer for the benefit of patients.