Life Out of Sequence

Author: Hallam Stevens
Publisher: University of Chicago Press
ISBN: 022608034X
Category : Science
Languages : en
Pages : 303

Book Description
Thirty years ago, the most likely place to find a biologist was standing at a laboratory bench, peering down a microscope, surrounded by flasks of chemicals and petri dishes full of bacteria. Today, you are just as likely to find him or her in a room that looks more like an office, poring over lines of code on computer screens. The use of computers in biology has radically transformed who biologists are, what they do, and how they understand life. In Life Out of Sequence, Hallam Stevens looks inside this new landscape of digital scientific work. Stevens chronicles the emergence of bioinformatics—the mode of working across and between biology, computing, mathematics, and statistics—from the 1960s to the present, seeking to understand how knowledge about life is made in and through virtual spaces. He shows how scientific data moves from living organisms into DNA sequencing machines, through software, and into databases, images, and scientific publications. What he reveals is a biology very different from the one of predigital days: a biology that includes not only biologists but also highly interdisciplinary teams of managers and workers; a biology that is more centered on DNA sequencing, but one that understands sequence in terms of dynamic cascades and highly interconnected networks. Life Out of Sequence thus offers the computational biology community welcome context for their own work while also giving the public a frontline perspective of what is going on in this rapidly changing field.

Sequence Analysis in a Nutshell: A Guide to Tools

Author: Scott Markel
Publisher: "O'Reilly Media, Inc."
ISBN: 9780596004941
Category : Computers
Languages : en
Pages : 308

Book Description
This work pulls together all of the vital information about the most commonly used databases, analytical tools, and tables used in sequence analysis.

Biological Sequence Analysis

Author: Richard Durbin
Publisher: Cambridge University Press
ISBN: 113945739X
Category : Science
Languages : en
Pages : 372

Book Description
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Sequence

Author: Lori Andrews
Publisher: Macmillan
ISBN: 9780312942458
Category : Fiction
Languages : en
Pages : 340

Book Description
Geneticist Alexandra Blake uses her expertise to investigate a serial killer plaguing military bases across the country, but when an another murder hits close to home, Alex and her boyfriend, a Texas congressman, find their lives in danger.

The Vital Question

Author: Nick Lane
Publisher:
ISBN: 9781781250372
Category : Cells
Languages : en
Pages : 0

Book Description
A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.

Advances in Sequence Analysis: Theory, Method, Applications

Author: Philippe Blanchard
Publisher: Springer
ISBN: 3319049690
Category : Social Science
Languages : en
Pages : 308

Book Description
This book gives a general view of sequence analysis, the statistical study of successions of states or events. It includes innovative contributions on life course studies, transitions into and out of employment, contemporaneous and historical careers, and political trajectories. The approach presented in this book is now central to the life-course perspective and the study of social processes more generally. This volume promotes the dialogue between approaches to sequence analysis that developed separately, within traditions contrasted in space and disciplines. It includes the latest developments in sequential concepts, coding, atypical datasets and time patterns, optimal matching and alternative algorithms, survey optimization, and visualization. Field studies include original sequential material related to parenting in 19th-century Belgium, higher education and work in Finland and Italy, family formation before and after German reunification, French Jews persecuted in occupied France, long-term trends in electoral participation, and regime democratization. Overall the book reassesses the classical uses of sequences and it promotes new ways of collecting, formatting, representing and processing them. The introduction provides basic sequential concepts and tools, as well as a history of the method. Chapters are presented in a way that is both accessible to the beginner and informative to the expert.

The Sequence to Success

Author: Samuel R. Chand
Publisher: Whitaker House
ISBN: 1641233923
Category : Business & Economics
Languages : en
Pages : 139

Book Description
Every one of us gets anywhere in life due to three things: someone observes us, forms an opinion about us, and decides to give us an opportunity…or not. Likewise, we do the same thing with others. People have played this essential role in our lives, and we play it in the lives of those around us—and no matter how skilled we’ve become, we can play it even better. The sequence applies in business, the church, marriages, parenting, and friendships. We often assess others in the blink of an eye. We instinctively notice the look on someone’s face, the tone of voice, or the body language that’s consistent or different from the words being spoken. We react to our observation, but we seldom stop to analyze before we respond—it just happens, and it happens immediately: we observe and have an opinion, and based on what we’ve determined in that second, we either give the person an opportunity to engage with us or we close the door and remain guarded. The Sequence to Success: Three O’s That Will Take You Anywhere in Life is a leadership book, but it’s not limited to corporate presidents, CEOs, or lead pastors; it’s for everyone who has a position of influence in another person’s life—and that includes all of us. In this book, Sam Chand brings our subconscious assumptions into the light. With more insight and confidence, you’ll make better decisions to advance the people around you…or perhaps show them the door. These principles also help you become more conscious that people are observing you and forming opinions about you that will open or close doors of opportunity.

Bioinformatics

Author: Hamid D. Ismail
Publisher: CRC Press
ISBN: 1000519074
Category : Science
Languages : en
Pages : 469

Book Description
Bioinformatics: A Practical Guide to NCBI Databases and Sequence Alignments provides the basics of bioinformatics and in-depth coverage of NCBI databases, sequence alignment, and NCBI Sequence Local Alignment Search Tool (BLAST). As bioinformatics has become essential for life sciences, the book has been written specifically to address the need of a large audience including undergraduates, graduates, researchers, healthcare professionals, and bioinformatics professors who need to use the NCBI databases, retrieve data from them, and use BLAST to find evolutionarily related sequences, sequence annotation, construction of phylogenetic tree, and the conservative domain of a protein, to name just a few. Technical details of alignment algorithms are explained with a minimum use of mathematical formulas and with graphical illustrations. Key Features Provides readers with the most-used bioinformatics knowledge of bioinformatics databases and alignments including both theory and application via illustrations and worked examples. Discusses the use of Windows Command Prompt, Linux shell, R, and Python for both Entrez databases and BLAST. The companion website (http://www.hamiddi.com/instructors/) contains tutorials, R and Python codes, instructor materials including slides, exercises, and problems for students. This is the ideal textbook for bioinformatics courses taken by students of life sciences and for researchers wishing to develop their knowledge of bioinformatics to facilitate their own research.

DIY MFA

Author: Gabriela Pereira
Publisher: Penguin
ISBN: 1599639343
Category : Language Arts & Disciplines
Languages : en
Pages : 306

Book Description
Get the Knowledge Without the College! You are a writer. You dream of sharing your words with the world, and you're willing to put in the hard work to achieve success. You may have even considered earning your MFA, but for whatever reason--tuition costs, the time commitment, or other responsibilities--you've never been able to do it. Or maybe you've been looking for a self-guided approach so you don't have to go back to school. This book is for you. DIY MFA is the do-it-yourself alternative to a Master of Fine Arts in creative writing. By combining the three main components of a traditional MFA--writing, reading, and community--it teaches you how to craft compelling stories, engage your readers, and publish your work. Inside you'll learn how to: • Set customized goals for writing and learning. • Generate ideas on demand. • Outline your book from beginning to end. • Breathe life into your characters. • Master point of view, voice, dialogue, and more. • Read with a "writer's eye" to emulate the techniques of others. • Network like a pro, get the most out of writing workshops, and submit your work successfully. Writing belongs to everyone--not only those who earn a degree. With DIY MFA, you can take charge of your writing, produce high-quality work, get published, and build a writing career.

Sequence — Evolution — Function

Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
ISBN: 1475737831
Category : Science
Languages : en
Pages : 482

Book Description
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.