Author: R. A. Mrode Publisher: ISBN: 9781780643908 Category : Livestock Languages : en Pages : 343
Book Description
This book contains 17 chapters that describe the use of statistical analyses and models to estimate, analyse and compare the genetic parameters, breeding value and performance traits of livestock. Each chapter contains the theories and actual application of the concepts. The book has been compiled from various publications and experience in the subject area and from involvement in several national evaluation schemes over the last 14 years. Relevant references are included to indicate sources of some of the materials.
Author: R. A. Mrode Publisher: Cab International ISBN: 9781845939816 Category : Technology & Engineering Languages : en Pages : 343
Book Description
The prediction of producing desirable traits in offspring such as increased growth rate or superior meat, milk and wool production is a vital economic tool to the animal scientist. Summarizing the latest developments in genomics relating to animal breeding values and design of breeding programs, this new edition includes models of survival analysis, social interaction and sire and dam models, as well as advancements in the use of SNPs in the computation of genomic breeding values.
Author: Raphael Mrode Publisher: CABI ISBN: 1800620489 Category : Technology & Engineering Languages : en Pages : 409
Book Description
Fundamental to any livestock improvement programme by animal scientists, is the prediction of genetic merit in the offspring generation for desirable production traits such as increased growth rate, or superior meat, milk and wool production. Covering the foundational principles on the application of linear models for the prediction of genetic merit in livestock, this new edition is fully updated to incorporate recent advances in genomic prediction approaches, genomic models for multi-breed and crossbred performance, dominance and epistasis. It provides models for the analysis of main production traits as well as functional traits and includes numerous worked examples. For the first time, R codes for key examples in the textbook are provided online. Suitable for graduate and postgraduate students, researchers and lecturers of animal breeding, genetics and genomics, this established textbook provides a thorough grounding in both the basics and in new developments of linear models and animal genetics.
Author: Charles R. Henderson Publisher: Guelph, Ont. : University of Guelph ISBN: 9780889550308 Category : Amélioration génétique - Méthodes statistiques Languages : en Pages : 462
Author: Daniel Gianola Publisher: Springer Science & Business Media ISBN: 3642744877 Category : Technology & Engineering Languages : en Pages : 554
Book Description
Developments in statistics and computing as well as their application to genetic improvement of livestock gained momentum over the last 20 years. This text reviews and consolidates the statistical foundations of animal breeding. This text will prove useful as a reference source to animal breeders, quantitative geneticists and statisticians working in these areas. It will also serve as a text in graduate courses in animal breeding methodology with prerequisite courses in linear models, statistical inference and quantitative genetics.
Author: Fikret Isik Publisher: Springer ISBN: 3319551779 Category : Science Languages : en Pages : 409
Book Description
This book fills the gap between textbooks of quantitative genetic theory, and software manuals that provide details on analytical methods but little context or perspective on which methods may be most appropriate for a particular application. Accordingly this book is composed of two sections. The first section (Chapters 1 to 8) covers topics of classical phenotypic data analysis for prediction of breeding values in animal and plant breeding programs. In the second section (Chapters 9 to 13) we provide the concept and overall review of available tools for using DNA markers for predictions of genetic merits in breeding populations. With advances in DNA sequencing technologies, genomic data, especially single nucleotide polymorphism (SNP) markers, have become available for animal and plant breeding programs in recent years. Analysis of DNA markers for prediction of genetic merit is a relatively new and active research area. The algorithms and software to implement these algorithms are changing rapidly. This section represents state-of-the-art knowledge on the tools and technologies available for genetic analysis of plants and animals. However, readers should be aware that the methods or statistical packages covered here may not be available or they might be out of date in a few years. Ultimately the book is intended for professional breeders interested in utilizing these tools and approaches in their breeding programs. Lastly, we anticipate the usage of this volume for advanced level graduate courses in agricultural and breeding courses.
Author: Osval Antonio Montesinos López Publisher: Springer Nature ISBN: 3030890104 Category : Technology & Engineering Languages : en Pages : 707
Book Description
This book is open access under a CC BY 4.0 license This open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension.The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.
Author: David J. Balding Publisher: John Wiley & Sons ISBN: 1119429226 Category : Science Languages : en Pages : 1219
Book Description
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Author: Johannes W. R. Martini Publisher: Frontiers Media SA ISBN: 2889746747 Category : Science Languages : en Pages : 261
Book Description
Genomic selection (GS) has been the most prominent topic in breeding science in the last two decades. The continued interest is promoted by its huge potential impact on the efficiency of breeding. Predicting a breeding value based on molecular markers and phenotypic values of relatives may be used to manipulate three parameters of the breeder's equation. First, the accuracy of the selection may be improved by predicting the genetic value more reliably when considering the records of relatives and the realized genomic relationship. Secondly, genotyping and predicting may be more cost effective than comprehensive phenotyping. Resources can instead be allocated to increasing population sizes and selection intensity. The third, probably most important factor, is time. As shown in dairy cattle breeding, reducing cycle time by crossing selection candidates earlier may have the strongest impact on selection gain. Many different prediction models have been used, and different ways of using predicted values in a breeding program have been explored. We would like to address the questions: i. How did GS change breeding schemes of different crops in the last 20 years? ii. What was the impact on realized selection gain? iii. What would be the best structure of a crop-specific breeding scheme to exploit the full potential of GS? iv. What is the potential of hybrid prediction, epistasis effect models, deep learning methods and other extensions of the standard prediction of additive effects? v. What are the long-term effects of GS? vi. Can predictive breeding approaches also be used to harness genetic resources from germplasm banks in a more efficient way to adapt current germplasm to new environmental challenges? This Research Topic welcomes submissions of Original Research papers, Opinions, Perspectives, Reviews, and Mini-Reviews related to these themes: 1. Genomic selection: statistical methodology 2. The (optimal) use of GS in breeding schemes 3. Practical experiences with GS (selection gain, long-term effects, negative side effects) 4. Predictive approaches to harness genetic resources Concerning point 1): If an original research paper compares different methods empirically without theoretical considerations on when one or the other method should be better, the methods should be compared with at least five different data sets. The data sets should differ either in crop, genotyping method or its source, for instance from a breeding program or gene bank accessions. Concerning point 2): Manuscripts addressing the use of GS in breeding schemes should illustrate breeding schemes that are run in practice. General ideas about schemes that may be run in the future may be considered as 'Perspective' articles. Conflict of Interest statements: - Topic Editor Valentin Wimmer is affiliated to KWS SAAT SE & Co. KGaA, Germany. - Topic Editor Brian Gardunia is affiliated to Bayer Crop Sciences and has a collaboration with AbacusBio, and is an author on patents with Bayer Crop Sciences. The other Topic Editors did not disclose any conflicts of interest. Image credit: CIMMYT, reproduced under the CC BY-NC-SA 2.0 license
Author: Basant K. Tiwary Publisher: Springer Nature ISBN: 9811642419 Category : Medical Languages : en Pages : 239
Book Description
This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.
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Author: R. A. Mrode
Author: R. A. Mrode
Author: Raphael Mrode
Author: Charles R. Henderson
Author: Daniel Gianola
Author: Fikret Isik
Author: Osval Antonio Montesinos López
Author: David J. Balding
Author: Johannes W. R. Martini
Author: Basant K. Tiwary