Double Blind

Author: Edward St. Aubyn
Publisher: Farrar, Straus and Giroux
ISBN: 0374717478
Category : Fiction
Languages : en
Pages : 256

Book Description
Double Blind follows three close friends and their circle through a year of extraordinary transformation. Set inLondon, Cap d'Antibes, Big Sur, and a rewilded corner of Sussex, this thrilling, ambitious novel is about the headlong pursuit of knowledge—for the purposes of pleasure, revelation, money, sanity, or survival—and the consequences of fleeing from what we know about others and ourselves. When Olivia meets a new lover just as she is welcoming her best friend, Lucy, back from New York, her dedicated academic life expands precipitously. Her connection to Francis, a committed naturalist living off the grid, is immediate and startling. Eager to involve Lucy in her joy, Olivia introduces the two—but Lucy has received shocking news of her own that binds the trio unusually close. Over the months that follow, Lucy’s boss, Hunter, Olivia’s psychoanalyst parents, and a young man named Sebastian are pulled into the friends’ orbit, and not one of them will emerge unchanged. Expansive, playful, and compassionate, Edward St. Aubyn's Double Blind investigates themes of inheritance, determinism, freedom, consciousness, and the stories we tell about ourselves. It is as compelling about ecology, psychoanalysis, genetics, and neuroscience as it is about love, fear, and courage. Most of all, it is a perfect expression of the interconnections it sets out to examine, and a moving evocation of an imagined world that is deeply intelligent, often tender, curious, and very much alive.

Doubleblind

Author: Ann Aguirre
Publisher: Penguin
ISBN: 1101140364
Category : Fiction
Languages : en
Pages : 276

Book Description
View our feature on Ann Aguirre’s Doubleblind.As a “Jumper” who navigates ships through grimspace, Sirantha Jax is used to kicking ass. So why is she suddenly chosen as an ambassador of peace?

Beyond the Double Bind

Author: Kathleen Hall Jamieson
Publisher: Oxford University Press, USA
ISBN: 0195089405
Category : Political Science
Languages : en
Pages : 298

Book Description
A breakthrough account of how women can overcome the social binds that block their success. As Kathleen Hall Jamieson explores society's interlaced traps and restrictions, she draws on hundreds of interviews with women from all walks of life to show the ways they can cut through the restrictions.

Double Cross Blind

Author: Joel N. Ross
Publisher: Anchor
ISBN: 1400078814
Category : Fiction
Languages : en
Pages : 383

Book Description
December 1, 1941It is seven days before the Japanese attack Pearl Harbor. Days that are numbered for Sondegger, a Nazi spy captured in London while on a mission to take down the Twenty Committee, a German network of spies the British have turned.For American Tom Wall, the days have run together as he awakens to find himself locked in a British military asylum. Wounded and shell-shocked, all he knows is that his brother, Earl, betrayed Tom’s unit in Crete, causing one of the bloodiest masacres of the war.Now Tom has to pretend to be his brother, and try to force Sondegger to reveal what he knows about the Twenty Committee. But Sondegger also knows about the Japanese plan of attack, and Tom may be able to prevent it. But should he?An electrifying debut that combines political insight with the classic elements of espionage fiction–here is a Nazi spy novel you won’t be able to put down.

Double Bind: Women on Ambition

Author: Robin Romm
Publisher: Liveright Publishing
ISBN: 1631491229
Category : Social Science
Languages : en
Pages : 330

Book Description
“Bold, absorbing, insightful, and wise. . . . Read it: the truth is inside.”— Cheryl Strayed, author of Wild and Tiny Beautiful Things “A work of courage and ferocious honesty” (Diana Abu-Jaber), Double Bind could not come at a more urgent time. Even as major figures from Gloria Steinem to Beyoncé embrace the word “feminism,” the word “ambition” remains loaded with ambivalence. Many women see it as synonymous with strident or aggressive, yet most feel compelled to strive and achieve—the seeming contradiction leaving them in a perpetual double bind. Ayana Mathis, Molly Ringwald, Roxane Gay, and a constellation of “nimble thinkers . . . dismantle this maddening paradox” (O, The Oprah Magazine) with candor, wit, and rage. Women who have made landmark achievements in fields as diverse as law, dog sledding, and butchery weigh in, breaking the last feminist taboo once and for all. “Both intimate and scalable” (Atlantic.com), Double Bind finally seizes “ambition” from the roster of dirty words.

Double-consciousness/double Bind

Author: Sandra Adell
Publisher: University of Illinois Press
ISBN: 9780252021091
Category : African Americans
Languages : en
Pages : 196

Book Description
"'It is a peculiar sensation, this double consciousness, this sense of always looking at one's self through the eyes of others.' For Adell, W. E. B. Du Bois's famous articulation of the 'twoness' of black Americans is the key to understanding the 'double bind' which afflicts contemporary African-American literary theory. . . . The book] demands and deserves recognition as a cogent intervention." -- Yearbook of English Studies

The Double Bind

Author: Chris Bohjalian
Publisher: Vintage
ISBN: 0307389413
Category : Fiction
Languages : en
Pages : 418

Book Description
NATIONAL BESTSELLER • From the bestselling author of The Flight Attendant, here is a gripping psychological novel of obsession and consequence. When Laurel Estabrook is attacked while riding her bicycle through Vermont’s back roads, her life is forever changed. Formerly outgoing, Laurel withdraws into her photography, spending all her free time at a homeless shelter. There she meets Bobbie Crocker, a man with a history of mental illness and a box of photographs that he won’t let anyone see. When Bobbie dies, Laurel discovers a deeply hidden secret–a story that leads her far from her old life, and into a cat-and-mouse game with pursuers who claim they want to save her. In a tale that travels between the Roaring Twenties and the twenty-first century, between Jay Gatsby’s Long Island and rural New England, bestselling author Chris Bohjalian has written an extraordinary novel. Look for Chris Bohjalian's new novel, The Lioness!

Planning Clinical Research

Author: Robert A. Parker
Publisher: Cambridge University Press
ISBN: 0521840635
Category : Mathematics
Languages : en
Pages : 445

Book Description
Planning clinical research requires many decisions. The authors of this book explain key decisions with examples showing what works and what does not.

Field Trials of Health Interventions

Author: Peter G. Smith
Publisher:
ISBN: 0198732864
Category : Health & Fitness
Languages : en
Pages : 479

Book Description
This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.

Small Clinical Trials

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309171148
Category : Medical
Languages : en
Pages : 221

Book Description
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.